GRAVIOLA - FOLHAS

 100 CÁPSULAS DE 600 MG

Propriedades / Acções Documentadas por Pesquisa:

Antibacteriana, anticancerígena, antiespasmódica, anti-histamínica, antifúngica, antimalárica, antimutagénica (protectora celular), antiparasitária, antitumoral, cardiodepressora,  hipotensora,  sedativa, uterino estimulante, vasodilatadora.

Alguns compostos foram documentadas por serem selectivos citotóxicos para as células mutantes com a glicoproteína-P e suas funções de bombeio. Estas bombas de fluxo intercelulares podem ser encontradas também na Candida albicans, nas células cancerosas, fungos e em bactérias multirresistentes, tendo propriedades anticancerígenas  10 000 vezes mais potentes que a quimioterapia.

Usos tradicionais:  Os povos indígenas usam-na como antiviral, cardiotónica, descongestionante, digestiva estimulante, febrífuga, nas depressões, para a circulação e no combate a diversos parasitas. No cancro e leucemias, como estimulante das funções imunes e na produção de células imunes.

 

Ingredientes: Annona muricata, folhas.

Sugestão de uso: Tome 3 cápsulas (500 mg cada) 3 x dia.

Contra-Indicações: Não deve ser usado durante a gravidez ou durante a amamentação.

Interacções  medicamentosas: Nenhuma relatada.

 

Precauções:  Cardiodepressora, vasodilatadora e hipotensora (baixa a pressão arterial). Dosagens grandes podem causar náusea e vómito. Evite combinar com precursores do ATP, CoQ10 ou similar.

Deve ser tomada em conjunto com o Probiosan®

 

PESQUISAS E ESTUDOS PUBLICADOS POR PESQUISADORES SOBRE A GRAVIOLA

Anticancerous & Antitumor Actions:
Torres, M., et al. "Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism." Cancer Lett. 2012 Oct 1;323(1):29-40.
de Pedro N, et al. "Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I." J Bioenerg Biomembr. 2012 Nov 21. [Epub ahead of print]
de Pedro N, et al. "Mitochondrial complex I inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway." J Bioenerg Biomembr. 2012 Nov 21. [Epub ahead of print]
Hamizah, S., et al. "Chemopreventive potential of Annona muricata L leaves on chemically-induced skin papillomagenesis in mice." Asian Pac J Cancer Prev. 2012;13(6):2533-9.
Chen, Y., et al. "Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds." J Ethnopharmacol. 2012 Jul 13;142(2):462-6.
Chen, Y., et al. "Antitumor activity of annonaceous acetogenins in HepS and S180 xenografts bearing mice." Bioorg Med Chem Lett. 2012 Apr 15;22(8):2717-9.
George, V., et al. "Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines." Asian Pac J Cancer Prev. 2012;13(2):699-704.
Gomes de Melo, J., et al. "Antiproliferative activity, antioxidant capacity and tannin content in plants of semi-arid northeastern Brazil." Molecules. 2010 Nov 24;15(12):8534-42.
Ko, Y., et al. "Annonacin induces cell cycle-dependent growth arrest and apoptosis in estrogen receptor-?-related pathways in MCF-7 cells." J Ethnopharmacol. 2011 Oct 11;137(3):1283-90.
Tantithanaporn, S., et al. "Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. root extracts against a lung cancer cell line (COR-L23)." Phytomedicine. 2011 Apr 15;18(6):486-90.
Coothankandaswamy, V., et al. "The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway." J Nat Prod. 2010 May 28;73(5):956-61.
Yang, h., et al. "Structure-activity relationships of diverse annonaceous acetogenins against human tumor cells." Bioorg Med Chem Lett. 2009 Apr 15;19(8):2199-202.
Kojima, N. “Systematic synthesis of antitumor Annonaceous acetogenins” Yakugaku Zasshi. 2004; 124(10): 673-81.
Tormo, J. R., et al. “In vitro antitumor structure-activity relationships of threo/trans/threo mono-tetrahydro-furanic acetogenins: Correlations with their inhibition of mitochondrial complex I.” Oncol. Res. 2003; 14(3): 147-54.
Yuan, S. S., et al. “Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway.” Life Sci. 2003 May: 72(25): 2853-61.
Liaw, C. C., et al. “New cytotoxic monotetrahydrofuran Annonaceous acetogenins from Annona muricata.J. Nat. Prod. 2002; 65(4): 470-75
Gonzalez-Coloma, A., et al. “Selective action of acetogenin mitochondrial complex I inhibitors.” Z. Naturforsch. 2002; 57(11-12): 1028-34.
Chang, F. R., et al. “Novel cytotoxic Annonaceous acetogenins from Annona muricata.J. Nat. Prod. 2001; 64(7): 925-31.
Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.” Fitoterapia. 2000; 71 (2): 183-6.
Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal plant extracts.” Mem. Inst. Oswaldo Cruz. 1999; 94(4): 531-35.
Kim, G. S., et al. “Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata.Phytochemistry. 1998; 49(2): 565-71.
Kim, G. S., et al. “Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata.J. Nat. Prod. 1998; 61(4): 432-36.
Nicolas, H., et al. “Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.” J. Med. Chem. 1997; 40(13): 2102-6.
Zeng, L., et al. “Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata.J. Nat. Prod. 1996; 59(11): 1035-42.
Wu, F. E., et al. “Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata.J. Nat. Prod. 1995; 58(6): 830-36.
Oberlies, N. H., et al. “Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assay.” Cancer Lett. 1995; 96(1): 55-62.
Wu, F. E., et al. “Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata.J. Nat. Prod. 1995; 58(9): 1430-37.
Wu, F. E., et al. “New bioactive monotetrahydrofuran Annonaceous acetogenins, annomuricin C and muricatocin C, from the leaves of Annona muricata.J. Nat. Prod. 1995; 58(6): 909-5.
Wu, F. E., et al. “Muricatocins A and B, two new bioactive monotetrahydrofuran Annonaceous acetogenins from the leaves of Annona muricata.J. Nat. Prod. 1995; 58(6): 902-8.
Sundarrao, K., et al. “Preliminary screening of antibacterial and antitumor activities of Papua New Guinean native medicinal plants.” Int. J. Pharmacog. 1993; 31(1): 3-6.

Antimicrobial Actions:
Feng, L., et al. "Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae." Bioorg Med Chem. 2011 Jun 1;19(11):3512-9.
Viera, G., et al. "Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria." Rev Inst Med Trop Sao Paulo. 2010 May-Jun;52(3):129-32.
Takahashi, J.A., et al. “Antibacterial activity of eight Brazilian Annonaceae plants.” Nat. Prod. Res. 2006; 20(1): 21-6.
Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal plant extracts.” Mem. Inst. Oswaldo Cruz 1999; 94(4): 531-35.
Antoun, M. D., et al. "Evaluation of the flora of Puerto Rico for in vitro cytotoxic and anti-HIV activities." Pharmaceutical Biol. 1999; 37(4): 277-280.
Padma, P., et al. “Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus.” J. Ethnopharmacol. 1998; 61(1): 81–3.
Sundarrao, K., et al. “Preliminary screening of antibacterial and antitumor activities of Papua New Guinean native medicinal plants.” Int. J. Pharmacog. 1993; 31(1): 3–6.
Misas, C. A. J., et al. “Contribution to the biological evaluation of Cuban plants. IV.” Rev. Cubana Med. Trop. 1979; 31(1): 29–35.

Antidepressant & Antistress Actions:
Padma, P., et al. “Effect of Annona muricata and Polyalthia cerasoides on brain neurotransmitters and enzyme monoamine oxidase following cold immobilization stress.” J. Natural Remedies 2001; 1(2): 144–46.
Hasrat, J. A., et al. “Screening of medicinal plants from Suriname for 5-HT 1A ligands: Bioactive isoquinoline alkaloids from the fruit of Annona muricata.” Phytomedicine. 1997; 4(20: 133-140.
Padma, P., et al. “Effect of alcohol extract of Annona muricata on cold immobilization stress induced tissue lipid peroxidation.” Phytother. Res. 1997; 11(4): 326-327.
Hasrat, J. A., et al. “Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead) products.” J. Pharm. Pharmacol. 1997; 49(11): 1145–49.

Antiparasitic, Antimalarial, & Insecticidal Actions:
Grzybowski, A., et al. "Synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of Annona muricata and Piper nigrum against the dengue fever vector Aedes aegypti." Pest Manag Sci. 2012 Sep 19. doi: 10.1002/ps.3409. [Epub ahead of print]
Vila-Nova N., et al. "Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil." Rev Soc Bras Med Trop. 2011 Oct;44(5):567-71.
Broglio-Micheletti S., et al. "[Plant extracts in control of Rhipicephalus (Boophilus) microplus (Canestrini, 1887) (Acari: Ixodidae) in laboratory]." Rev Bras Parasitol Vet. 2009 Oct-Dec;18(4):44-8.
Osorio, E., et al. "Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae." J Ethnopharmacol. 2007 May 22;111(3):630-5.
Luna, J. S., et al. “Acetogenins in Annona muricata L. (Annonaceae) leaves are potent molluscicides.” Nat. Prod. Res. 2006; 20(3): 253-7.
Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.” Fitoterapia. 2000; 71(2): 183–6.
Alali, F. Q., et al. “Annonaceous acetogenins as natural pesticides; potent toxicity against insecticide-susceptible and resistant German cockroaches (Dictyoptera: Blattellidae).” J. Econ. Entomol. 1998; 91(3): 641-9.
Antoun, M. D., et al. "Screening of the flora of Puerto Rico for potential antimalarial bioactives.” Int. J. Pharmacog. 1993; 31(4): 255–58.
Heinrich, M., et al. “Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico).” J. Ethnopharmacol. 1992; 36(1): 81–5.
Bories, C., et al. “Antiparasitic activity of Annona muricata and Annona cherimolia seeds.” Planta Med. 1991; 57(5): 434–36.
Gbeassor, M., et al. “In vitro antimalarial activity of six medicinal plants.” Phytother. Res. 1990; 4(3): 115–17.
Tattersfield, F., et al. “The insecticidal properties of certain species of Annona and an Indian strain of Mundulea sericea (Supli).” Ann. Appl. Biol. 1940; 27: 262–73.

Anti-Diabetes Action:
Adeyemi, D., et al. "Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of Annona muricata." Folia Morphol (Warsz). 2010 May;69(2):92-100.
Adeyemi, D., et al. "Anti hyperglycemic activities of Annona muricata (Linn)" Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):62-9.
Adewole, S., et al. "Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats." Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):30-41.

Anticonvulsant, Antispasmodic, & Smooth Muscle Relaxant Actions:
N’gouemo, P., et al. “Effects of ethanol extract of Annona muricata on pentylenetetrazol-induced convulsive seizures in mice.” Phytother. Res. 1997; 11(3): 243–45.
Feng, P. C., et al. “Pharmacological screening of some West Indian medicinal plants.” J. Pharm. Pharmacol. 1962; 14: 556–61.

Hypotensive & Cardiodepressant Actions
Nwokocha, C., et al. "Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague-Dawley rats." Pharm Biol. 2012 Nov;50(11):1436-41.
Carbajal, D., et al. “Pharmacological screening of plant decoctions commonly used in Cuban folk medicine.” J. Ethnopharmacol. 1991; 33(1/2): 21–4.
Feng, P. C., et al. “Pharmacological screening of some West Indian medicinal plants.” J. Pharm. Pharmacol. 1962; 14: 556–61.
Meyer, T. M. “The alkaloids of Annona muricata.” Ing. Ned. Indie. 1941; 8(6): 64.

Pain-Relieving & Anti-inflammatory Actions:
de Sousa, O., et al. "Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models." Int J Mol Sci. 2010 May 6;11(5):2067-78

Antioxidant Actions:
Nawwar, M., et al. "A flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata Linn." Arch Pharm Res. 2012 May;35(5):761-7.
Adewole, S., et al. "Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats." Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):30-41.
Baskar, R., et al. "In vitro antioxidant studies in leaves of Annona species." Indian J Exp Biol. 2007 May;45(5):480-5.

 

 

Graviola  100 Cápsulas de 600 mg    Preço: 26.35€ .  Portes gratuitos se for  antecipadamente pago por MB ou transferência. À cobrança + 6.00€ - só para Portugal

Encomendas pelo telf:. 21 726 12 09 ou por email:vidarmonia.geral@vidarmonia.pt

  

Preços incluem IVA a taxa legal em vigor - preços podem ser alterados sem aviso prévio. Material sujeito a disponibilidade de stock.