100 CÁPSULAS DE 600 MG
Propriedades / Acções
Documentadas por Pesquisa:
Antibacteriana,
anticancerígena, antiespasmódica, anti-histamínica,
antifúngica, antimalárica, antimutagénica (protectora
celular), antiparasitária, antitumoral,
cardiodepressora, hipotensora, sedativa,
uterino estimulante, vasodilatadora.
Alguns compostos foram documentadas por serem
selectivos citotóxicos para as células mutantes com a
glicoproteína-P e suas funções de bombeio. Estas bombas
de fluxo intercelulares podem ser encontradas também na
Candida albicans, nas células cancerosas, fungos e em
bactérias multirresistentes, tendo propriedades
anticancerígenas 10 000 vezes mais potentes que a
quimioterapia.
Usos
tradicionais: Os povos indígenas
usam-na como antiviral, cardiotónica, descongestionante,
digestiva estimulante, febrífuga, nas depressões, para a
circulação e no combate a diversos parasitas.
Ingredientes: Annona
muricata, folhas.
Sugestão de uso:
Tome 3
cápsulas (500 mg cada) 3
x dia.
Contra-Indicações:
Não deve ser usado
durante a gravidez ou
durante a amamentação.
Interacções
medicamentosas: Nenhuma relatada.
Precauções:
Cardiodepressora,
vasodilatadora e hipotensora (baixa a pressão
arterial). Dosagens grandes podem causar náusea e
vómito. Evite combinar com precursores do ATP, CoQ10
ou similar.
Deve ser tomada em conjunto com o Probiosan®
PESQUISAS E ESTUDOS PUBLICADOS POR PESQUISADORES SOBRE A GRAVIOLA
Anticancerous & Antitumor Actions:
Torres, M.,
et al. "Graviola: a novel promising natural-derived drug
that inhibits tumorigenicity and metastasis of
pancreatic cancer cells in vitro and in vivo through
altering cell metabolism." Cancer Lett. 2012 Oct
1;323(1):29-40.
de Pedro N, et al. "Analysis of
cytotoxic activity at short incubation times reveals
profound differences among Annonaceus acetogenins,
inhibitors of mitochondrial Complex I." J Bioenerg
Biomembr. 2012 Nov 21. [Epub ahead of print]
de
Pedro N, et al. "Mitochondrial complex I inhibitors,
acetogenins, induce HepG2 cell death through the
induction of the complete apoptotic mitochondrial
pathway." J Bioenerg Biomembr. 2012 Nov 21. [Epub
ahead of print]
Hamizah, S., et al. "Chemopreventive
potential of Annona muricata L leaves on
chemically-induced skin papillomagenesis in mice."
Asian Pac J Cancer Prev. 2012;13(6):2533-9.
Chen, Y., et al. "Anti-tumor activity of Annona squamosa
seeds extract containing annonaceous acetogenin
compounds." J Ethnopharmacol. 2012 Jul
13;142(2):462-6.
Chen, Y., et al. "Antitumor
activity of annonaceous acetogenins in HepS and S180
xenografts bearing mice." Bioorg Med Chem Lett.
2012 Apr 15;22(8):2717-9.
George, V., et al.
"Quantitative assessment of the relative antineoplastic
potential of the n-butanolic leaf extract of Annona
muricata Linn. in normal and immortalized human cell
lines." Asian Pac J Cancer Prev.
2012;13(2):699-704.
Gomes de Melo, J., et al.
"Antiproliferative activity, antioxidant capacity and
tannin content in plants of semi-arid northeastern
Brazil." Molecules. 2010 Nov 24;15(12):8534-42.
Ko, Y., et al. "Annonacin induces cell
cycle-dependent growth arrest and apoptosis in estrogen
receptor-?-related pathways in MCF-7 cells." J
Ethnopharmacol. 2011 Oct 11;137(3):1283-90.
Tantithanaporn, S., et al. "Cytotoxic activity of
acetogenins and styryl lactones isolated from
Goniothalamus undulatus Ridl. root extracts against a
lung cancer cell line (COR-L23)." Phytomedicine.
2011 Apr 15;18(6):486-90.
Coothankandaswamy, V., et
al. "The alternative medicine pawpaw and its acetogenin
constituents suppress tumor angiogenesis via the
HIF-1/VEGF pathway." J Nat Prod. 2010 May
28;73(5):956-61.
Yang, h., et al.
"Structure-activity relationships of diverse annonaceous
acetogenins against human tumor cells." Bioorg Med
Chem Lett. 2009 Apr 15;19(8):2199-202.
Kojima,
N. “Systematic synthesis of antitumor Annonaceous
acetogenins” Yakugaku Zasshi. 2004; 124(10):
673-81.
Tormo, J. R., et al. “In vitro
antitumor structure-activity relationships of
threo/trans/threo mono-tetrahydro-furanic acetogenins:
Correlations with their inhibition of mitochondrial
complex I.” Oncol. Res. 2003; 14(3): 147-54.
Yuan, S. S., et al. “Annonacin, a mono-tetrahydrofuran
acetogenin, arrests cancer cells at the G1 phase and
causes cytotoxicity in a Bax- and caspase-3-related
pathway.” Life Sci. 2003 May: 72(25): 2853-61.
Liaw, C. C., et al. “New cytotoxic
monotetrahydrofuran Annonaceous acetogenins from
Annona muricata.” J. Nat. Prod. 2002; 65(4):
470-75
Gonzalez-Coloma, A., et al. “Selective action
of acetogenin mitochondrial complex I inhibitors.” Z.
Naturforsch. 2002; 57(11-12): 1028-34.
Chang, F.
R., et al. “Novel cytotoxic Annonaceous acetogenins from
Annona muricata.” J. Nat. Prod. 2001;
64(7): 925-31.
Jaramillo, M. C., et al.
“Cytotoxicity and antileishmanial activity of Annona
muricata pericarp.” Fitoterapia. 2000; 71
(2): 183-6.
Betancur-Galvis, L., et al. “Antitumor
and antiviral activity of Colombian medicinal plant
extracts.” Mem. Inst. Oswaldo Cruz. 1999; 94(4):
531-35.
Kim, G. S., et al. “Muricoreacin and
murihexocin C, mono-tetrahydrofuran acetogenins, from
the leaves of Annona muricata.” Phytochemistry.
1998; 49(2): 565-71.
Kim, G. S., et al. “Two new
mono-tetrahydrofuran ring acetogenins, annomuricin E and
muricapentocin, from the leaves of Annona muricata.”
J. Nat. Prod. 1998; 61(4): 432-36.
Nicolas,
H., et al. “Structure-activity relationships of diverse
Annonaceous acetogenins against multidrug resistant
human mammary adenocarcinoma (MCF-7/Adr) cells.” J.
Med. Chem. 1997; 40(13): 2102-6.
Zeng, L., et
al. “Five new monotetrahydrofuran ring acetogenins from
the leaves of Annona muricata.” J. Nat. Prod.
1996; 59(11): 1035-42.
Wu, F. E., et al. “Two new
cytotoxic monotetrahydrofuran Annonaceous acetogenins,
annomuricins A and B, from the leaves of Annona
muricata.” J. Nat. Prod. 1995; 58(6): 830-36.
Oberlies, N. H., et al. “Tumor cell growth
inhibition by several Annonaceous acetogenins in an
in vitro disk diffusion assay.” Cancer Lett.
1995; 96(1): 55-62.
Wu, F. E., et al. “Additional
bioactive acetogenins, annomutacin and (2,4-trans and
cis)-10R-annonacin-A-ones, from the leaves of Annona
muricata.” J. Nat. Prod. 1995; 58(9):
1430-37.
Wu, F. E., et al. “New bioactive
monotetrahydrofuran Annonaceous acetogenins, annomuricin
C and muricatocin C, from the leaves of Annona
muricata.” J. Nat. Prod. 1995; 58(6): 909-5.
Wu, F. E., et al. “Muricatocins A and B, two new
bioactive monotetrahydrofuran Annonaceous acetogenins
from the leaves of Annona muricata.” J. Nat.
Prod. 1995; 58(6): 902-8.
Sundarrao, K., et al.
“Preliminary screening of antibacterial and antitumor
activities of Papua New Guinean native medicinal
plants.” Int. J. Pharmacog. 1993; 31(1): 3-6.
Antimicrobial Actions:
Feng, L., et al.
"Specific inhibitions of annonaceous acetogenins on
class II 3-hydroxy-3-methylglutaryl coenzyme A reductase
from Streptococcus pneumoniae." Bioorg Med Chem.
2011 Jun 1;19(11):3512-9.
Viera, G., et al.
"Antibacterial effect (in vitro) of Moringa oleifera and
Annona muricata against Gram positive and Gram negative
bacteria." Rev Inst Med Trop Sao Paulo. 2010
May-Jun;52(3):129-32.
Takahashi, J.A., et al.
“Antibacterial activity of eight Brazilian Annonaceae
plants.” Nat. Prod. Res. 2006; 20(1): 21-6.
Betancur-Galvis, L., et al. “Antitumor and antiviral
activity of Colombian medicinal plant extracts.” Mem.
Inst. Oswaldo Cruz 1999; 94(4): 531-35.
Antoun,
M. D., et al. "Evaluation of the flora of Puerto Rico
for in vitro cytotoxic and anti-HIV activities."
Pharmaceutical Biol. 1999; 37(4): 277-280.
Padma, P., et al. “Effect of the extract of Annona
muricata and Petunia nyctaginiflora on Herpes
simplex virus.” J. Ethnopharmacol. 1998; 61(1):
81–3.
Sundarrao, K., et al. “Preliminary screening
of antibacterial and antitumor activities of Papua New
Guinean native medicinal plants.” Int. J. Pharmacog.
1993; 31(1): 3–6.
Misas, C. A. J., et al.
“Contribution to the biological evaluation of Cuban
plants. IV.” Rev. Cubana Med. Trop. 1979; 31(1):
29–35.
Antidepressant & Antistress Actions:
Padma, P., et al. “Effect of Annona muricata
and Polyalthia cerasoides on brain
neurotransmitters and enzyme monoamine oxidase following
cold immobilization stress.” J. Natural Remedies
2001; 1(2): 144–46.
Hasrat, J. A., et al. “Screening
of medicinal plants from Suriname for 5-HT 1A ligands:
Bioactive isoquinoline alkaloids from the fruit of
Annona muricata.” Phytomedicine. 1997; 4(20:
133-140.
Padma, P., et al. “Effect of alcohol
extract of Annona muricata on cold immobilization
stress induced tissue lipid peroxidation.” Phytother.
Res. 1997; 11(4): 326-327.
Hasrat, J. A., et al.
“Isoquinoline derivatives isolated from the fruit of
Annona muricata as 5-HTergic 5-HT1A receptor
agonists in rats: unexploited antidepressive (lead)
products.” J. Pharm. Pharmacol. 1997; 49(11):
1145–49.
Antiparasitic, Antimalarial, &
Insecticidal Actions:
Grzybowski, A., et al.
"Synergistic larvicidal effect and morphological
alterations induced by ethanolic extracts of Annona
muricata and Piper nigrum against the dengue fever
vector Aedes aegypti." Pest Manag Sci. 2012 Sep
19. doi: 10.1002/ps.3409. [Epub ahead of print]
Vila-Nova N., et al. "Leishmanicidal activity and
cytotoxicity of compounds from two Annonacea species
cultivated in Northeastern Brazil." Rev Soc Bras Med
Trop. 2011 Oct;44(5):567-71.
Broglio-Micheletti
S., et al. "[Plant extracts in control of Rhipicephalus
(Boophilus) microplus (Canestrini, 1887) (Acari:
Ixodidae) in laboratory]." Rev Bras Parasitol Vet.
2009 Oct-Dec;18(4):44-8.
Osorio, E., et al.
"Antiprotozoal and cytotoxic activities in vitro of
Colombian Annonaceae." J Ethnopharmacol. 2007 May
22;111(3):630-5.
Luna, J. S., et al. “Acetogenins in
Annona muricata L. (Annonaceae) leaves are potent
molluscicides.” Nat. Prod. Res. 2006; 20(3):
253-7.
Jaramillo, M. C., et al. “Cytotoxicity and
antileishmanial activity of Annona muricata
pericarp.” Fitoterapia. 2000; 71(2): 183–6.
Alali, F. Q., et al. “Annonaceous acetogenins as natural
pesticides; potent toxicity against
insecticide-susceptible and resistant German cockroaches
(Dictyoptera: Blattellidae).” J. Econ.
Entomol. 1998; 91(3): 641-9.
Antoun, M. D., et
al. "Screening of the flora of Puerto Rico for potential
antimalarial bioactives.” Int. J. Pharmacog.
1993; 31(4): 255–58.
Heinrich, M., et al.
“Parasitological and microbiological evaluation of Mixe
Indian medicinal plants (Mexico).” J. Ethnopharmacol.
1992; 36(1): 81–5.
Bories, C., et al. “Antiparasitic
activity of Annona muricata and Annona
cherimolia seeds.” Planta Med. 1991; 57(5):
434–36.
Gbeassor, M., et al. “In vitro
antimalarial activity of six medicinal plants.”
Phytother. Res. 1990; 4(3): 115–17.
Tattersfield, F., et al. “The insecticidal properties of
certain species of Annona and an Indian strain of
Mundulea sericea (Supli).” Ann. Appl. Biol.
1940; 27: 262–73.
Anti-Diabetes Action:
Adeyemi, D., et al. "Histomorphological and
morphometric studies of the pancreatic islet cells of
diabetic rats treated with extracts of Annona muricata."
Folia Morphol (Warsz). 2010 May;69(2):92-100.
Adeyemi, D., et al. "Anti hyperglycemic activities of
Annona muricata (Linn)" Afr J Tradit Complement
Altern Med. 2008 Oct 25;6(1):62-9.
Adewole, S.,
et al. "Protective effects of Annona muricata Linn.
(Annonaceae) leaf aqueous extract on serum lipid
profiles and oxidative stress in hepatocytes of
streptozotocin-treated diabetic rats." Afr J Tradit
Complement Altern Med. 2008 Oct 25;6(1):30-41.
Anticonvulsant, Antispasmodic, & Smooth Muscle
Relaxant Actions:
N’gouemo, P., et al. “Effects
of ethanol extract of Annona muricata on
pentylenetetrazol-induced convulsive seizures in mice.”
Phytother. Res. 1997; 11(3): 243–45.
Feng, P.
C., et al. “Pharmacological screening of some West
Indian medicinal plants.” J. Pharm. Pharmacol.
1962; 14: 556–61.
Hypotensive &
Cardiodepressant Actions
Nwokocha, C., et al.
"Possible mechanisms of action of the hypotensive effect
of Annona muricata (soursop) in normotensive
Sprague-Dawley rats." Pharm Biol. 2012
Nov;50(11):1436-41.
Carbajal, D., et al.
“Pharmacological screening of plant decoctions commonly
used in Cuban folk medicine.” J. Ethnopharmacol.
1991; 33(1/2): 21–4.
Feng, P. C., et al.
“Pharmacological screening of some West Indian medicinal
plants.” J. Pharm. Pharmacol. 1962; 14: 556–61.
Meyer, T. M. “The alkaloids of Annona muricata.”
Ing. Ned. Indie. 1941; 8(6): 64.
Pain-Relieving & Anti-inflammatory Actions:
de
Sousa, O., et al. "Antinociceptive and Anti-Inflammatory
Activities of the Ethanol Extract of Annona muricata L.
Leaves in Animal Models." Int J Mol Sci. 2010 May
6;11(5):2067-78
Antioxidant Actions:
Nawwar, M., et al. "A flavonol triglycoside and
investigation of the antioxidant and cell stimulating
activities of Annona muricata Linn." Arch Pharm Res.
2012 May;35(5):761-7.
Adewole, S., et al.
"Protective effects of Annona muricata Linn.
(Annonaceae) leaf aqueous extract on serum lipid
profiles and oxidative stress in hepatocytes of
streptozotocin-treated diabetic rats." Afr J Tradit
Complement Altern Med. 2008 Oct 25;6(1):30-41.
Baskar, R., et al. "In vitro antioxidant studies in
leaves of Annona species." Indian J Exp Biol.
2007 May;45(5):480-5.
Graviola 100 Cápsulas de 600 mg Preço: 26.35€ . Portes gratuitos se for antecipadamente pago por MB ou transferência. À cobrança + 6.00€ - só para Portugal
Encomendas pelo telf:. 21 726 12 09 ou por email:vidarmonia.geral@vidarmonia.pt
Preços incluem IVA a taxa legal em vigor - preços podem ser alterados sem aviso prévio. Material sujeito a disponibilidade de stock.